Balancing Survival and Cognition: The Hidden Costs of Methotrexate in Pediatric ALL

In this episode, we delve into the complex world of pediatric Acute Lymphoblastic Leukemia (ALL) treatment, focusing on the vital role of methotrexate. While it boasts a remarkable cure rate exceeding 90%, this powerful drug poses significant neurotoxic risks that can hinder cognitive development in young patients. Join us as we explore the long-term impacts on memory, attention, and executive function, and discuss innovative solutions like personalized medicine and genetic profiling aimed at mitigating these effects. Discover how we can better balance life-saving treatments with the need for a bright future!