Unraveling Cyclophosphamide: Species-Specific Metabolism and Its Impact on Cancer Treatment

Join us as we dive into the fascinating world of cyclophosphamide metabolism across different species—humans, dogs, cats, and mice. Discover how this prodrug transforms in the body and the crucial role of liver enzymes, particularly cytochrome P450s, in its activation. Uncover why dog microsomes are significantly more efficient than human ones, leading to vital implications for drug dosing and effectiveness in veterinary and human medicine. This episode sheds light on the complexities of pharmacokinetics and the importance of comparative oncology in advancing cancer treatments.